PLANT-BASED EMOLLIENTS
Sunflower and Jojoba Oils, combined with an olive oil-derived emulsifier, Behenyl Alcohol, and Vitamin E, create a synergistic network of emollients capable of penetrating deeply into the skin, providing nourishment, protection against external aggressors, and continuous hydration.

 AGE REFRAME COMPLEX
Age Reframe Complex is an advanced blend of cosmetic active ingredients that delivers a synergistic action on four key levels of skin longevity. It combines Alpine Rose Extract, Apple Stem Cell Extract, Grape Stem Cell Extract, and Niacinamide to target several hallmarks of skin ageing through an integrated approach, helping promote skin cell longevity, resilience, and regeneration.
Alpine Stem Cell Extract
Rich in taxifolin and farrerol, two compounds structurally similar to fisetin, a well-known senolytic agent, Alpine Rose Extract helps support healthy skin renewal. Taxifolin modulates β-catenin-related cellular pathways involved in cell maturation, differentiation, proliferation, and repair. Farrerol helps reduce the expression of genes that inhibit apoptosis, promoting the natural removal of senescent (“zombie”) cells and supporting tissue renewal.
Apple Stem Cell Extract
Apple Stem Cell Extract supports the replacement of senescent cells eliminated through senolytic processes by stimulating the formation of new dermal precursor cells. These immature dermal cells can differentiate into healthy, functional fibroblasts, helping restore skin vitality. In vitro studies have demonstrated an increase in extracellular matrix (ECM) production. Additionally, Apple Stem Cell Extract promotes keratinocyte growth at the basement membrane, enhancing epidermal renewal and improving overall skin thickness.
Grape Stem Cell Extract
Grape Stem Cell Extract stimulates the regenerative capacity of epidermal precursor cells located above the basement membrane, which are responsible for the continuous renewal of the epidermis and its natural desquamation process. Constant exposure to UV radiation and other endogenous stressors can impair their function; Grape Stem Cell Extract helps counteract these effects by reducing irritation and preserving cellular vitality.

Niacinamide
Niacinamide enhances the regenerative potential initiated by the other active ingredients by supporting cellular function and energy metabolism. As a precursor of the NAD⁺/NADH system, it plays a key role in maintaining cellular homeostasis and energy production. Within the epidermis, it promotes ceramide biosynthesis, strengthening the skin barrier. In the dermis, it helps regulate melanogenesis and supports extracellular matrix (ECM) organization, resulting in a smoother, more even, and visibly healthier complexion.

KALIGEN PDRN CHICORY™
Kaligen PDRN Chicory™ is a vegan nucleobiotic obtained through a biofermentation process using chicory oligosaccharides as a functional substrate. This innovative process is designed to optimize the production of nucleotides and nucleic acids, reaching a concentration of up to 90% in the final extract. The supply of these biomacromolecules supports skin renewal, hydration, and plumping processes by enhancing the activity of native collagen. As a result, it promotes smoother, firmer, and visibly younger-looking skin. Its efficacy has been demonstrated in vitro on human fibroblasts, where it increased cellular vitality by +138% and enhanced protein synthesis, supporting dermal functionality. The active ingredient also showed positive results in a scratch assay model, indicating its ability to promote fibroblast migration, and increased Collagen I gene expression. In vivo, on volunteers showing signs of skin ageing, wrinkle profilometry demonstrated a clear improvement compared with placebo, particularly on forehead wrinkles and glabellar lines. Thanks to its regenerative and restructuring properties, Kaligen PDRN Chicory™ is particularly suitable for skin showing signs of ageing, fatigue, loss of firmness, and reduced elasticity.

Ergothioneine
is a histidine-derived molecule with a biomimetic cytoprotective antioxidant action, designed to support the skin against oxidative stress caused by UV exposure, pollution, and cellular metabolism. Thanks to a specific cellular transporter, Ergothioneine is efficiently taken up by skin cells, where it protects sensitive biological structures by neutralizing ROS (Reactive Oxygen Species) and other reactive molecules generated by environmental stressors, pollution, and cellular processes. In this way, it helps reduce oxidative damage affecting DNA, proteins, and lipids. Ergothioneine indirectly supports the skin matrix, collagen structure, and barrier function. It also inhibits tyrosinase activity, helping reduce melanin formation and persistence. By preserving extracellular matrix (ECM) homeostasis within the dermis, Ergothioneine helps maintain skin luminosity, vitality, and overall quality, especially in skin exposed to environmental stress.